Edward Harry Gerstin, Jr.
1408 38th Avenue, San Francisco, CA 94122
Incyte Genomics, 3160 Porter Drive, Palo Alto, CA 94304 (650) 845-4692
Senior Scientist/Scientist, IP Bioinformatics, Incyte Genomics, Palo Alto, CA
Patent Writer, Legal Department, Incyte Genomics, Palo Alto, CA
Post-doctoral Fellow, Ernest Gallo Clinic & Research Center, Department of Neurology University of California, San Francisco
Ph.D. in Pharmacology and Toxicology, Department of Pharmacology, College of Medicine University of California, Irvine
B.A. in Biochemistry and Cell Biology, Department of Biology University of California, San Diego
• Co-lead a team of programmers and bioinformatics associates in the definition, design, development, testing, and production deployment of methods for data analysis, data flow, and data management in the Intellectual Property (IP) department
• Interface with IP department staff to develop innovative methods for high-throughput patent application and prosecution processes
• Act as liaison between IP department and Research, Bioinformatics, and Product Science departments to develop data and methods supporting Legal department functionsMaintain IP Bioinformatics data quality, including gene assemblies, hand-edited full length genes, expression data, genomic data, and annotation data
• Participate in the design, development, and implementation of an Oracle-based sequence tracking database, as well as accompanying user interface
• Wrote numerous patent applications, and provided scientific input for patent prosecution
• Studied the PKC-dependent regulation of L-type calcium channels by chronic ethanol treatment, in the model neuronal cell line PC12
• Wrote an NIH grant application for postdoctoral funding; funding awarded in 1996
• Characterized muscarinic acetylcholine receptor subtypes in rat peripheral lung by analyzing the pharmacological antagonism of second messenger responses
• Studied the modulation of G-protein coupled receptor signaling pathways in three different tissues using radioligand binding and second messenger assays
• Bioinformatics/sequence analysis programs (HMMER, BLAST, BLIMPS, GCG)
• PERL programming, including writing, testing, and implementing numerous PERL scripts
• UNIX, Macintosh and PC environment
• Courses in Relational Database Design, Introductory and Intermediate SQL
• Molecular biology techniques, including RT-PCR, northern analysis, nucleic acid extraction/manipulation, subcloning, and ribonuclease protection assays
• Biochemical analyses of second messenger levels, including cAMP accumulation, adenylate cyclase activity assays, and inositol phosphate accumulation assays, with extensive assay modification/optimization
• Screening agonists using second messenger assays in various tissue preparations
• Cell culture methods
NIAAA Grant, NRSA Postdoctoral Fellowship
Henry Wood Elliott Award, for Outstanding Graduate Student in Pharmacology
University of California Regents Fellowship
Student Representative, Self Study Task Force of Liaison Committee on Medical Education
Vice President - Internal Affairs, Associated Graduate Students
Military Duty
Specialist E4, US Army Biomedical Research and Development Laboratory, Fort Detrick, MD
Modulation of Muscarinic Signaling
UMI Dissertation Services, Ann Arbor, MI, 1996
PKC Isozymes That Mediate Chronic Responses to Ethanol, Annual Meeting of the Research Society on Alcoholism
Toxicology of the Central Nervous System and Eye, in Pharmacological Principles of Toxicology, University of California, Irvine